In 1939 Poland, Antonina Żabińska (Jessica Chastain) and her husband, Dr. Jan Żabiński (Johan Heldenbergh), have the Warsaw Zoo flourishing under his stewardship and her care. When their country is invaded by the Germans, Jan and Antonina are stunned and forced to report to the Reich's newly appointed chief zoologist, Lutz Heck (Daniel Brühl). To fight back on their own terms, the Żabińskis covertly begin working with the Resistance and put into action plans to save lives out of what has become the Warsaw Ghetto, with Antonina putting herself and even her children at great risk.