With fresh memories of his family's slaughter by Red Leg soldier Terrill (Bill McKinney), Confederate Josey Wales (Eastwood) refuses to join his captain Fletcher (John Vernon) and the rest of his comrades in surrender to a U.S. Army regiment. Deemed a dangerous outlaw after a bloody one-man battle with that regiment, Josey is pursued by U.S. Cavalry soldiers led by the unwilling Fletcher and the murderous Terrill, as well as by bounty hunters who eventually learn how coolly lethal Wales can be. Despite his desire to remain a lone fugitive, Josey soon has a crew of travelling companions that includes Cherokee Lone Watie (Chief Dan George) and the pretty Laura Lee (Sondra Locke) and her vigorous Grandma Sarah (Paula Trueman), settlers on their way to a ranch near Santa Rio. The few Santa Rio residents welcome the group, but their peace and Josey's burgeoning romance with Laura Lee are soon interrupted by Terrill's arrival.