Giovanni, the leader of Team Rocket, had ambitious plans to take over the world, involving his latest experiment, a powerful clone of Mew, Mewtwo. Mewtwo is very powerful, and also very smart-smart, enough to not want to be controlled by Giovanni. It escaped from the lab, and now Mewtwo begins to concoct its own scheme, clandestinely inviting a number of Pokemon Trainers to the ultimate test.