During the early 1990s, San Francisco was the epicenter of body modification and gender nonconformity, with transgender pioneers like Patrick Califia and Tala Brandeis fighting for visibility, alongside the voice of a bold S/M community. From pushy bottoms to macho femmes, BLOODSISTERS immerses the viewer in the San Francisco leather dyke scene, shattering assumptions about gender and lesbian sexuality, while broadening the discussion about personal expressions of eroticism and their political implications.