Six lepers have escaped from a nearby colony where they've been ostracized. These fugitive immediately head toward the nearby town and break into a house where they ravage the food supply of an elderly couple. The next morning, a posse forms with the goal of capturing and executing the escapees. Even worse, an enterprising group of outlaws realize they can form an uneasy alliance with the lepers for their own. Santo appears to sort things out and provide justice where it is needed most.