17-year-old sociopath John Wayne Cleaver is working with a group of demon-hunting FBI agents and their advisors, all of whom have relocated to the Midwestern town of Fort Bruce in pursuit of evil metahumans called Withered. John's Withered-possessed friend and possible love interest, Brooke Watson, has been deposited in an assisted living center in Fort Bruce for safekeeping; when she reports another Withered in town, events escalate, with the hunters soon becoming the hunted.