Two years have passed since elite police officer Damien Tomasso teamed up with reformed vigilante Leito to save the notorious District 13, a racially charged ghetto populated by violent drug-dealing gangs and vicious killers. Despite government promises to maintain order, the state of the district has deteriorated and is causing civil unrest. A group of corrupt cops and elected officials conspire to cash in on the district's redevelopment. by proposing its destruction. Damian and Leito must join forces again, using their martial arts and unique physical skills to bring peace to the neighborhood by any means necessary.