Set in Indiana in 1987, Pike Ables is charged with a murder he can't remember amid a heroin withdrawal. Now, he must make a decision: go to jail or head for the Canadian border to start a new life. His only hope is his younger brother, Jack, a frustrated psychiatrist and soon-to-be father who is ready to leave everything behind, including his pregnant wife, to try and save him. Things aren't as they seem when the brothers try to navigate out of the darkness and into the light. With no food or drugs, and only a few wet cigarettes, the two embark on a journey that tests the meaning of love, family, forgiveness, life, and death.