Can a sacred plant medicine from the Amazon heal our minds and spirits? In the heart of the jungle, a naturopathic doctor and an accountant experience life-altering epiphanies when they drink the psychoactive brew ayahuasca, the 'Vine of the Soul'. This award-winning documentary explores the mystery of ayahuasca shamanism, offering insights into the nature of spirituality, mystical experience and self-healing discovered through an expanded state of consciousness. Is ayahuasca a doorway to direct knowledge of the divine or a path that leads to psychological trauma? Can it cure modern addictions to drugs and alcohol or is ayahuasca itself a possible substance of abuse? Some call it a medicine, others a sacrament; the Amazonian shamans say it is simply a 'plant teacher' that tells you what you need to know. Interviews with indigenous and Western shamans, ethnobotanist Dennis McKenna, addiction expert Dr. Gabor Maté and scholar Kenneth Tupper speak to the increasing use of ayahuasca outside the Amazon and the potential benefits for Western medicine, personal spiritual growth and a new understanding of Nature.