When their favorite bar is threatened with closure, outlaw biker Harley (Mickey Rourke) and modern-day cowboy Marlboro (Don Johnson) hatch a plot to save the day - by robbing the corrupt bank behind the bar's shutdown! But when the robbery yields not money but a shipment of drugs, the duo finds themselves on the run from the bank's president (Tom Sizemore) and a posse of hit men. Now wanted dead or alive, they learn that when the going gets tough, the tough take the law into their own hands!