Tess is in Florence on an idyllic vacation before starting university in London. Gus is also visiting Florence, on a holiday with his parents seven months after tragedy shattered their lives. Headed to medical school in London, he's trying to be a dutiful son but longs to escape and discover who he really is. A chance meeting brings these eighteen-year-olds together for a brief moment, the first of many times their paths will crisscross as time passes and their lives diverge from those they'd envisioned. Over the course of the next sixteen years, Tess and Gus will face very different challenges and choices. Separated by distance and circumstance, the possibility of these two connecting once more seems slight. But while fate can separate two people, it can also bring them back together again.