After Catherine Wells' ship experiences a deadly incident in deep space and loses contact with NASA, the entire world believes her dead. Miraculously and mysteriously she survived, but with little memory of what happened. Her reentry after a decade away is a turbulent one: her husband has moved on with another woman, and the young daughter she left behind has grown into a teenager she barely recognizes. Catherine, too, is different. The long years alone changed her, and as she readjusts to being home, sometimes she feels disconnected and even, at times, deep rage toward her family and colleagues. There are periods of time she can't account for, too, and she begins waking up in increasingly strange and worrisome locations, like restricted areas of NASA. Suddenly she's questioning everything that happened up in space: how her crewmates died, how she survived, and now, what's happening to her back on Earth.