Over the past three decades, speedrunners have been collaboratively digging for secrets, working to uncover mind-blowing shortcuts and glitches which are used to streamline their runs. Running with Speed follows top runners, from the past and present, of gaming franchises that are pillars in speedrunning: Super Mario Bros., The Legend of Zelda, and Metroid. World records in these retro classics are especially revered. The series culminates at the 10 year anniversary of Games Done Quick as runners use their prowess to raise millions of dollars from more than 80 countries to fight cancer.